PRP or Platelet-rich plasma is the plasma with a high concentration of platelets in it. It is derived from the patient’s blood, after centrifugation in a temperature-controlled centrifuge machine.
Human blood is a unique vital fluid that performs many basic functions in the human body, and has many key roles in maintaining the nutrition of the body’s organs and their efficiency. Human blood consists of a mixture of red and white blood cells and platelets, contained in a white, yellowish liquid called plasma, which gives the blood liquid consistency and helps in its flow and movement within the blood vessels.
Platelets are the cells that are responsible for the formation of blood clot, to prevent bleeding after an injury. Another important role of platelets is the release of platelet-derived growth factors, to help in wound healing. Release of growth factors also helps in stimulating stem cells of hair follicle for their growth. This function of platelet is used in PRP therapy.
As for the plasma, it consists of a homogeneous mixture of some basic proteins, which represent about 7%, such as globulin, albumin, fibrinogen, and water, which represents about 92% of plasma formation, facilitates movement, dissolving materials, and transporting various organic and inorganic materials as well as to maintain body temperature. Plasma components also include some inorganic ions, such as chlorine, phosphate, potassium, and magnesium, which work to maintain cell pressure.
How platelet-rich plasma (PRP) works – Indore
Treatment with platelet-rich plasma is the process of preparing and condensing platelets in pure plasma extracted from human blood itself, and this intensification is by 300-700%, where the proportion of intense platelets in the extracted plasma reaches around 1,000,000 platelets. Stimulating alpha granules in platelets triggers the release of many proteins, which contain growth factors – transformed growth factors, epidermal growth factors, insulin-like growth factors, and fibroblast growth factors. These growth factors that were released from the platelets work on the stem cells that are already in the hair follicle, stimulating the growth of the follicles and stimulating the blood supply.
How does platelet rich plasma work to stop hair loss?
Human blood contains platelets and autologous blood products that have certain growth factors that help in tissue healing and cell regrowth. And it has been confirmed for more than two decades that it is safe to use the autologous blood and blood products as medication for the healing of the skin
Platelet-rich plasma injection stimulates the scalp to produce protein and collagen, which are essential components of the middle layer of the dermis and have an effective role in maintaining the vitality and freshness of the skin. Protein and collagen production stimulates the scalp to produce new hair and strengthen weak hair. Thus PRP ( Platelet-rich plasma ) stimulates stem cells to regenerate and repair damaged and naturally divided cells with the help of growth factors. There is no scientific evidence of the possibility of creating new stem cells, but only just a process of stimulation of the stem cells that already exist. PRP therapy is not the same as stem cell therapy. On the balding scalp, PRP helps in promoting the growth of the miniaturized hair.
How do we perform this process?
Around 25ml of blood is drawn from a normal healthy individual, without any blood disorder or deficiency. This quantity is then placed in a centrifuge and administered at a specified speed in order for the platelets to be separated and deposited in the plasma. These condensed platelets are taken from the patient’s own blood and prepared by the advanced centrifuge machine, which has high efficiency in separating the platelets from any other device. It is a closed sterilization system that concentrates platelets more than three times the normal concentration in a patient’s blood. After that, taking all aseptic precautions, this platelet-rich plasma is injected directly into the patient’s scalp, specifically in the middle layer of the epidermis. The thinner bore needle used during the process gives very little pain, also the vibrator is used during the process makes it almost pain-free. After the PRP we advise the patient to avoid head wash and minoxidil application on the same day.
What makes platelet-rich plasma effective in treating hair loss? – Indore
Platelet-rich plasma stimulates hair follicles to produce hair and stop hair loss, thanks to the growth factors present in platelets that promote the growth of the hair follicles by acting on stem cells. This is the natural process if the blood flow to the hair follicles is sufficient. In platelet-rich plasma therapy, the treatment concentrates growth factors in the areas that need to stop hair loss and re-germinate the new hair.
The platelets that perform this treatment contain the following growth factors:
Platelet-derived growth factor (PDGF): This factor supports vascular growth, the transcription and division of cells, skin formation and regeneration, and is a key factor in supporting the scalp and hair growth.
Beta Transformation Growth Factor (TGF_b): This factor supports the growth of intracellular membranes and supports bone metabolism.
Skin Growth Factor (FGF): Supports cell growth, vascular formation and collagen production.
Vascular membrane growth factor (VEGF): supports the production and formation of blood vessels.
Fibroblast Growth Factor (FGF-2): aids the growth of specialized cells in follicle growth and vascular formation.
Insulin-like growth factor (IGF): it regulates the normal physiological processes of all cells of the body.
Candidates for PRP Therapy – PRP in Indore
Almost all people are fit for plasma injections to stop hair loss. Cases of genetic baldness or if you suffer from a scar on the scalp that hinders hair growth or alopecia areata, similar to various skin diseases of the head, or any other cause of hair loss. Even if the cause is unknown, plasma injection of hair is a very safe procedure and has no side effects because it is carried out by the patient’s own blood.
Those who suffer from low blood platelets in the blood may not be the appropriate person for such treatment. People with diabetes may be good candidates for plasma injections, but patients with “unregulated” diabetes may not be good for this procedure, given the effect of severe sugar changes on the blood and plasma elements themselves, and also greatly affects blood flow and the quality of growth factors in platelets. Liver patients and those suffering from liver viruses are not eligible for these procedures. We may also not recommend making this injection for those with chronic heart disease who suffer from heart muscle failure.
